Publications

Data-independent Acquisition Proteomics of Cerebrospinal Fluid Implicates Endoplasmic Reticulum and Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis.

Dellar ER, Vendrell I, Talbot K, Kessler BM, Fischer R, Turner MR, Thompson AG

December 2023 | Journal article | Journal of Neurochemistry | Read

Mass Spectrometry in Cerebrospinal Fluid Uncovers Association of Glycolysis Biomarkers with Alzheimer's Disease in a Large Clinical Sample.

de Geus MB, Leslie SN, Lam T, Wang W, Roux-Dalvai F, Droit A, Kivisakk P, Nairn AC, Arnold SE, Carlyle BC

December 2023 | Journal article | Scientific Reports | Read

Mutant GGGGCC RNA Prevents YY1 from Binding to Fuzzy Promoter which Stimulates Wnt/β-catenin Pathway in C9ALS/FTD.

Chen ZS, Ou M, Taylor S, Dafinca R, Peng SI, Talbot K, Chan HYE

December 2023 | Journal article | Nature Communications | Read

Mechanisms of aquaporin-4 Vesicular Trafficking in Mammalian Cells.

Markou A, Kitchen P, Aldabbagh A, Repici M, Salman MM, Bill RM, Balklava Z

December 2023 | Journal article | Journal of Neurochemistry | Read

Correction: Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-deficient Neurons.

Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L

December 2023 | Journal article | Molecular Neurodegeneration | Read

The PfRCR Complex Bridges Malaria Parasite and Erythrocyte During Invasion.

Farrell B, Alam N, Hart MN, Jamwal A, Ragotte RJ, Walters-Morgan H, Draper SJ, Knuepfer E, Higgins MK

December 2023 | Journal article | Nature | Read

Multilayer DNA Origami with Terminal Interfaces That Are Flat and Wide-Area.

Kilwing L, Lill P, Nathwani B, Guerra R, Benson E, Liedl T, Shih WM

December 2023 | Journal article | ACS Nano | Read

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease.

Yan S, Jiang C, Janzen A, Barber TR, Seger A, Sommerauer M, Davis JJ, Marek K, Hu MT, Oertel WH, Tofaris GK

December 2023 | Journal article | JAMA Neurology | Read

Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-deficient Neurons.

Hasan S, Fernandopulle MS, Humble SW, Frankenfield AM, Li H, Prestil R, Johnson KR, Ryan BJ, Wade-Martins R, Ward ME, Hao L

November 2023 | Journal article | Molecular Neurodegeneration | Read

Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling.

Hickman SJ, Miller HL, Bukys A, Kapanidis AN, Berks BC

November 2023 | Journal article | Journal of Molecular Biology | Read

Molecular Basis for Selective Uptake and Elimination of Organic Anions in the Kidney by OAT1.

Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S

November 2023 | Journal article | Nature Structural & Molecular Biology | Read

Penguins Snatch Seconds-long Microsleeps.

Harding CD, Vyazovskiy VV

November 2023 | Journal article | Science | Read

Deep Learning and Single-cell Phenotyping for Rapid Antimicrobial Susceptibility Detection in Escherichia coli.

Zagajewski A, Turner P, Feehily C, El Sayyed H, Andersson M, Barrett L, Oakley S, Stracy M, Crook D, Nellåker C, Stoesser N, Kapanidis AN

November 2023 | Journal article | Communications Biology | Read

Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.

Yan S, Jiang C, Davis JJ, Tofaris GK

November 2023 | Journal article | Brain | Read

Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.

Krone LB, Fehér KD, Rivero T, Omlin X

November 2023 | Journal article | Journal of Sleep Research | Read

Trypanosomes and Complement: More Than One Way to Die?

Cook AD, Carrington M, Higgins MK

November 2023 | Journal article | Trends in Parasitology | Read

Biocatalytic Reductive Amination as a Route to Isotopically Labelled Amino Acids Suitable for Analysis of Large Proteins by NMR.

Rowbotham JS, Nicholson JH, Ramirez MA, Urata K, Todd PMT, Karunanithy G, Lauterbach L, Reeve HA, Baldwin AJ, Vincent KA

November 2023 | Journal article | Chemical Science | Read

Innovative Method for Rapid Detection of Falsified COVID-19 Vaccines through Unopened Vials Using Handheld Spatially Offset Raman Spectroscopy (SORS).

Mosca S, Lin Q, Stokes R, Bharucha T, Gangadharan B, Clarke R, Fernandez LG, Deats M, Walsby-Tickle J, Arman BY, Chunekar SR, Patil KD, Gairola S, Van Assche K, Dunachie S, Merchant HA, Kuwana R, Maes A, McCullagh J, Caillet C, Zitzmann N, Newton PN, Matousek P

October 2023 | Journal article | Vaccine | Read

Erythrocyte Invasion-neutralising Antibodies Prevent Plasmodium Falciparum RH5 from Binding to Basigin-containing Membrane Protein Complexes.

Jamwal A, Constantin CF, Hirschi S, Henrich S, Bildl W, Fakler B, Draper SJ, Schulte U, Higgins MK

October 2023 | Journal article | Elife | Read

A Quinolin-8-ol Sub-millimolar Inhibitor of UGGT, the ER Glycoprotein Folding Quality Control Checkpoint.

Guay KP, Ibba R, Kiappes JL, Vasiljević S, Bonì F, De Benedictis M, Zeni I, Le Cornu JD, Hensen M, Chandran AV, Kantsadi AL, Caputo AT, Blanco Capurro JI, Bayo Y, Hill JC, Hudson K, Lia A, Brun J, Withers SG, Martí M, Biasini E, Santino A, De Rosa M, Milani M, Modenutti CP, Hebert DN, Zitzmann N, Roversi P

October 2023 | Journal article | iScience | Read

Structural Basis for Triacylglyceride Extraction from Mycobacterial Inner Membrane by MFS Transporter Rv1410.

Remm S, De Vecchis D, Schöppe J, Hutter CAJ, Gonda I, Hohl M, Newstead S, Schäfer LV, Seeger MA

October 2023 | Journal article | Nature Communications | Read

Single Particle Chemical Characterisation of Nanoformulations for Cargo Delivery.

Saunders C, de Villiers CA, Stevens MM

October 2023 | Journal article | The AAPS Journal | Read

Patient-derived iPSC Models of Friedreich Ataxia: A New Frontier for Understanding Disease Mechanisms and Therapeutic Application.

Maheshwari S, Vilema-Enríquez G, Wade-Martins R

September 2023 | Journal article | Translational Neurodegeneration | Read

A New Twist on PIFE: Photoisomerisation-related Fluorescence Enhancement.

Ploetz E, Ambrose B, Barth A, Börner R, Erichson F, Kapanidis AN, Kim HD, Levitus M, Lohman TM, Mazumder A, Rueda D, Steffen FD, Cordes T, Magennis S, Lerner E

September 2023 | Journal article | Methods and Applications in Fluorescence | Read

Trypanosomes and Complement: More than One Way to Die?

Cook AD, Carrington M, Higgins MK

September 2023 | Journal article | Trends in Parasitology | Read

Astrocytes in Functional Recovery Following Central Nervous System Injuries.

Alhadidi QM, Bahader GA, Arvola O, Kitchen P, Shah ZA, Salman MM

September 2023 | Journal article | The Journal of Physiology | Read

PRMT Inhibitor Promotes SMN2 Exon 7 Inclusion and Synergizes with Nusinersen to Rescue SMA Mice.

Kordala AJ, Stoodley J, Ahlskog N, Hanifi M, Garcia Guerra A, Bhomra A, Lim WF, Murray LM, Talbot K, Hammond SM, Wood MJ, Rinaldi C

September 2023 | Journal article | EMBO Molecular Medicine | Read

C9orf72-ALS Human iPSC Microglia are Pro-inflammatory and Toxic to Co-cultured Motor Neurons via MMP9.

Vahsen BF, Nalluru S, Morgan GR, Farrimond L, Carroll E, Xu Y, Cramb KML, Amein B, Scaber J, Katsikoudi A, Candalija A, Carcolé M, Dafinca R, Isaacs AM, Wade-Martins R, Gray E, Turner MR, Cowley SA, Talbot K

September 2023 | Journal article | Nature Communications | Read

Mitochondrial Dysfunction and Mitophagy Defects in LRRK2-R1441C Parkinson's Disease Models.

Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Malpartida AB, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R

September 2023 | Journal article | Human Molecular Genetics | Read

Infrared Multiphoton Dissociation Enables Top-Down Characterization of Membrane Protein Complexes and G Protein-Coupled Receptors.

Lutomski CA, El-Baba TJ, Hinkle JD, Liko I, Bennett JL, Kalmankar NV, Dolan A, Kirschbaum C, Greis K, Urner LH, Kapoor P, Yen HY, Pagel K, Mullen C, Syka JEP, Robinson CV

September 2023 | Journal article | Angewandte Chemie | Read

Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson's Disease Patients Carrying the Heterozygous Mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1.

Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D, Grünewald A, Schwamborn JC, Krüger R

September 2023 | Journal article | Stem Cell Research | Read

The Dual Action of Human Antibodies Specific to Plasmodium Falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites.

Weiss GE, Ragotte RJ, Quinkert D, Lias AM, Dans MG, Boulet C, Looker O, Ventura OD, Williams BG, Crabb BS, Draper SJ, Gilson PR

September 2023 | Journal article | PLoS Pathogens | Read

Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.

Cole BA, Becker EBE

September 2023 | Journal article | Cells | Read

Structural Characterization of Human Urea Transporters UT-A and UT-B and Their Inhibition.

Chi G, Dietz L, Tang H, Snee M, Scacioc A, Wang D, Mckinley G, Mukhopadhyay SMM, Pike ACW, Chalk R, Burgess-Brown NA, Timmermans JP, van Putte W, Robinson CV, Dürr KL

September 2023 | Journal article | Science Advances | Read

Continuous Home Cage Monitoring of Activity and Sleep in Mice During Repeated Paroxetine Treatment and Discontinuation.

Collins HM, Pinacho R, Tam SKE, Sharp T, Bannerman DM, Peirson SN

August 2023 | Journal article | Psychopharmacology | Read

Correction to "Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease".

Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC

August 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read

Transcending Markov: Non-Markovian Rate Processes of Thermosensitive TRP Ion Channels.

Ben-Abu Y, Tucker SJ, Contera S

August 2023 | Journal article | Royal Society Open Sci | Read

Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.

Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M

August 2023 | Journal article | Molecular & Cellular Proteomics | Read

Advantages of Routine Next-generation Sequencing Over Standard Genetic Testing in the Amyotrophic Lateral Sclerosis Clinic.

Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K

August 2023 | Journal article | European Journal of Neuralogy | Read

RNA Polymerase Redistribution Supports Growth in E. coli Strains with a Minimal Number of rRNA Operons.

Fan J, El Sayyed H, Pambos OJ, Stracy M, Kyropoulos J, Kapanidis AN

August 2023 | Journal article | Nucleic Acids Research | Read

A Quantitative Description for Optical Mass Measurement of Single Biomolecules.

Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P

August 2023 | Journal article | ACS Photonics | Read

Superior Antibody Immunogenicity of a Viral-vectored RH5 Blood-stage Malaria Vaccine in Tanzanian Infants as Compared to Adults.

Silk SE, Kalinga WF, Mtaka IM, Lilolime NS, Mpina M, Milando F, Ahmed S, Diouf A, Mkwepu F, Simon B, Athumani T, Rashid M, Mohammed L, Lweno O, Ali AM, Nyaulingo G, Mwalimu B, Mswata S, Mwamlima TG, Barrett JR, Wang LT, Themistocleous Y, King LDW, Hodgson SH, Payne RO, Nielsen CM, Lawrie AM, Nugent FL, Cho JS, Long CA, Miura K, Draper SJ, Minassian AM, Olotu AI

August 2023 | Journal article | Clinical Advances | Read

The Solute Carrier SPNS2 Recruits PI(4,5)P₂ to Synergistically Regulate Transport of Sphingosine-1-Phosphate.

Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV

August 2023 | Journal article | Molecular Science | Read

Structural Basis of Telomeric Nucleosome Recognition by Shelterin Factor TRF1.

Hu H, van Roon AM, Ghanim GE, Ahsan B, Oluwole AO, Peak-Chew SY, Robinson CV, Nguyen THD

August 2023 | Journal article | Science Advances | Read

ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.

Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL

August 2023 | Journal article | Journal of Proteome Research | Read

A Review of Broadly Protective Monoclonal Antibodies to Treat Ebola Virus Disease.

Rijal P, Donnellan FR

August 2023 | Journal article | Current Opinion in Virology | Read

Impaired Dopamine Release in Parkinson's Disease.

Cramb KML, Beccano-Kelly D, Cragg SJ, Wade-Martins R

August 2023 | Journal article | Brain | Read

Visualization of Direct and Diffusion-assisted RAD51 Nucleation by Full-length Human BRCA2 Protein.

Belan O, Greenhough L, Kuhlen L, Anand R, Kaczmarczyk A, Gruszka DT, Yardimci H, Zhang X, Rueda DS, West SC, Boulton SJ

July 2023 | Journal article | Molecular Cell | Read

The Solute Carrier SPNS2 Recruits PI(4,5)P₂ to Synergistically Regulate Transport of Sphingosine-1-Phosphate.

Tang H, Li H, Prakaash D, Pedebos C, Qiu X, Sauer DB, Khalid S, Duerr K, Robinson CV

July 2023 | Journal article | Molecular Cell | Read

Molecular Basis for Selective Uptake and Elimination of Organic Anions in the Kidney by OAT1

Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S

July 2023 | Journal article | Nature Structural & Molecular Biology | Read

Correction: Limitations of Non-polarizable Force Fields in Describing Anion Binding Poses in Non-polar Synthetic Hosts

Seiferth D, Tucker SJ, Biggin PC

July 2023 | Journal article | Physical Chemistry Chemical Physics | Read

The Beauty and Complexity of the Small Heat Shock Proteins: A Report on the Proceedings of the Fourth Workshop on Small Heat Shock Proteins.

Ecroyd H, Bartelt-Kirbach B, Ben-Zvi A, Bonavita R, Bushman Y, Casarotto E, Cecconi C, Lau WCY, Hibshman JD, Joosten J, Kimonis V, Klevit R, Liberek K, McMenimen KA, Miwa T, Mogk A, Montepietra D, Peters C, Rocchetti MT, Saman D, Sisto A, Secco V, Strauch A, Taguchi H, Tanguay M, Tedesco B, Toth ME, Wang Z, Benesch JLP, Carra S

July 2023 | Journal article | Cell Stress and Chaperones | Read

Vaccination with Plasmodium vivax Duffy-binding Protein Inhibits Parasite Growth During Controlled Human Malaria Infection.

Hou MM, Barrett JR, Themistocleous Y, Rawlinson TA, Diouf A, Martinez FJ, Nielsen CM, Lias AM, King LDW, Edwards NJ, Greenwood NM, Kingham L, Poulton ID, Khozoee B, Goh C, Hodgson SH, Mac Lochlainn DJ, Salkeld J, Guillotte-Blisnick M, Huon C, Mohring F, Reimer JM, Chauhan VS, Mukherjee P, Biswas S, Taylor IJ, Lawrie AM, Cho JS, Nugent FL, Long CA, Moon RW, Miura K, Silk SE, Chitnis CE, Minassian AM, Draper SJ

July 2023 | Journal article | Science Translational Medicine | Read

ProSight Native: Defining Protein Complex Composition from Native Top-Down Mass Spectrometry Data.

Durbin KR, Robey MT, Voong LN, Fellers RT, Lutomski CA, El-Baba TJ, Robinson CV, Kelleher NL

July 2023 | Journal article | Journal of Proteome Research | Read

​​​​​Dimerization of European Robin Cryptochrome 4a.

Hanić M, Antill LM, Gehrckens AS, Schmidt J, Görtemaker K, Bartölke R, El-Baba TJ, Xu J, Koch KW, Mouritsen H, Benesch JLP, Hore PJ, Solov'yov IA

July 2023 | Journal article | The Journal of Physical Chemistry | Read

Calcium Dysregulation Combined with Mitochondrial Failure and Electrophysiological Maturity Converge in Parkinson's iPSC-dopamine Neurons.

Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, Banerjee A, Vowles J, Cowley S, Wade-Martins R

July 2023 | Journal article | iScience | Read

Recent Advances in Membrane Mimetics for Membrane Protein Research.

Young JW

Jun 2023 | Journal article | Biochemical Society Transactions | Read

Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding.

Kümmerlin M, Mazumder A, Kapanidis AN

Jun 2023 | Journal article | ChemPhysChem | Read

Monitoring α-synuclein Ubiquitination Dynamics Reveals Key Endosomal Effectors Mediating its Trafficking and Degradation.

Zenko D, Marsh J, Castle AR, Lewin R, Fischer R, Tofaris GK

Jun 2023 | Journal article | Science Advances | Read

Mitochondrial Dysfunction and Mitophagy Defects in LRRK2-R1441C Parkinson's Disease Models.

Williamson MG, Madureira M, McGuinness W, Heon-Roberts R, Mock ED, Naidoo K, Cramb KML, Caiazza MC, Belen Malpartida A, Lavelle M, Savory K, Humble SW, Patterson R, Davis JB, Connor-Robson N, Ryan BJ, Wade-Martins R

Jun 2023 | Journal article | Human Molecular Genetics | Read

Effect of Temperature and Nucleotide on the Binding of BiP Chaperone to a Protein Substrate.

Rivera M, Burgos-Bravo F, Engelberger F, Asor R, Lagos-Espinoza MIA, Figueroa M, Kukura P, Ramírez-Sarmiento CA, Baez M, Smith SB, Wilson CAM

Jun 2023 | Journal article | Protein Science | Read

High-throughput Super-resolution Analysis of Influenza Virus Pleomorphism Reveals Insights into Viral Spatial Organization.

McMahon A, Andrews R, Groves D, Ghani SV, Cordes T, Kapanidis AN, Robb NC

Jun 2023 | Journal article | PLoS Pathogens | Read

Cross-linking Mass Spectrometry Uncovers Interactions Between High-density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.

Burnap SA, Ortega-Prieto AM, Jimenez-Guardeño JM, Ali H, Takov K, Fish M, Shankar-Hari M, Giacca M, Malim MH, Mayr M

Jun 2023 | Journal article | Molecular & Cellular Proteomics | Read

Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson's Disease Patients Carrying the Heterozygous Mutations c.815G > A (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1.

Chemla A, Arena G, Onal G, Walter J, Berenguer-Escuder C, Grossmann D, Grünewald A, Schwamborn JC, Krüger R

Jun 2023 | Journal article | Stem Cell Research | Read

RNA polymerase Redistribution Supports Growth in E. coli Strains with a Minimal Number of rRNA Operons.

Fan J, El Sayyed H, Pambos OJ, Stracy M, Kyropoulos J, Kapanidis AN

Jun 2023 | Journal article | Nucleic Acids Research | Read

Limitations of Non-polarizable Force Fields in Describing Anion Binding Poses in Non-polar Synthetic Hosts.

Seiferth D, Tucker SJ, Biggin PC

Jun 2023 | Journal article | Physical Chemistry Chemical Physics | Read

Rationalizing the Optimization of Detergents for Membrane Protein Purification.

Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV

May 2023 | Journal article | Chemistry Europe | Read

Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.

Yan S, Jiang C, Davis JJ, Tofaris GK

May 2023 | Journal article | Brain | Read

Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.

Krone LB, Fehér KD, Rivero T, Omlin X

May 2023 | Journal article | Journal of Sleep Research | Read

Single-molecule FRET for Virology: 20 Years of Insight into Protein Structure and Dynamics.

Groves D, Hepp C, Kapanidis AN, Robb NC

May 2023 | Journal article | Quarterly Reviews of Biophysics | Read

Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection.

Bharucha T, Gangadharan B, Kumar A, Myall AC, Ayhan N, Pastorino B, Chanthongthip A, Vongsouvath M, Mayxay M, Sengvilaipaseuth O, Phonemixay O, Rattanavong S, O'Brien DP, Vendrell I, Fischer R, Kessler B, Turtle L, de Lamballerie X, Dubot-Pérès A, Newton PN, Zitzmann N, SEAe Consortium

May 2023 | Journal article | Journal of Proteome Research | Read

α-Synuclein Fibril and Synaptic Vesicle Interactions Lead to Vesicle Destruction and Increased Lipid-Associated Fibril Uptake into iPSC-derived Neurons.

Stephens AD, Villegas AF, Chung CW, Vanderpoorten O, Pinotsi D, Mela I, Ward E, McCoy TM, Cubitt R, Routh AF, Kaminski CF, Kaminski Schierle GS

May 2023 | Journal article | Communications Biology | Read

A Modular RNA Delivery System Comprising Spherical Nucleic Acids Built on Endosome-escaping Polymeric Nanoparticles.

Garcia-Guerra A, Ellerington R, Gaitzsch J, Bath J, Kye M, Varela MA, Battaglia G, Wood MJA, Manzano R, Rinaldi C, Turberfield AJ.

May 2023 | Journal article | Nanoscale Advances | Read

Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson's Disease Diagnostics.

Sharafeldin M, Yan S, Jiang C, Tofaris GK, Davis JJ

May 2023 | Journal article | Analytical Chemistry | Read

Advantages of Routine Next Generation Sequencing Over Standard Genetic Testing in the ALS Clinic.

Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K

May 2023 | Journal article | Europen Journal of Neurology | Read

G Protein-Coupled Receptor Pharmacology-Insights from Mass Spectrometry

Yen HY, Jazayeri A, Robinson CV

May 2023 | Journal article | Pharmacological Reviews | Read

Temporal Transcriptional Control of Neural Induction in Human Induced Pluripotent Stem Cells

Gupta S, Polit LD, Fitzgerald M, Rowland HA, Murali D, Buckley NJ, Subramaniam S

May 2023 | Journal article | Frontiers in Molecular Neuroscience | Read

Reconfigurable Self-Assembled DNA Devices

Benson E, Bath J

April 2023 | Journal article | Science Robotics | Read

Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding

Kümmerlin M, Mazumder A, Kapanidis AN

April 2023 | Journal article | Chemphyschem | Read

Reliability and Accuracy of Single-molecule FRET Studies for Characterization of Structural Dynamics and Distances in Proteins

Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T

April 2023 | Journal article | Nature Methods | Read

Shapeshifting Bullvalene-linked Vancomycin Dimers as Effective Antibiotics Against Multidrug-resistant Gram-positive Bacteria

Ottonello A, Wyllie JA, Yahiaoui O, Sun S, Koelln RA, Homer JA, Johnson RM, Murray E, Williams P, Bolla JR, Robinson CV, Fallon T, Soares da Costa TP, Moses JE

April 2023 | Journal article | PNAS | Read

Fortuitously Compatible Protein Surfaces Primed Allosteric Control in Cyanobacterial Photoprotection

Steube N, Moldenhauer M, Weiland P, Saman D, Kilb A, Rojas AAR, Garg SG, Schindler D, Graumann PL, Benesch JLP, Bange G, Friedrich T, Hochberg GKA

April 2023 | Journal article | Nature Ecology & Evolution | Read

Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease

Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC

March 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read

An in-solution Snapshot of SARS-COV-2 Main Protease Maturation Process and Inhibition

Noske GD, Song Y, Fernandes RS, Chalk R, Elmassoudi H, Koekemoer L, Owen CD, El-Baba TJ, Robinson CV, COVID Moonshot Consortium, Oliva G, Godoy AS 

March 2023 | Journal article | Nature Communications | Read

Influence of Electronic Polarization on the Binding of Anions to a Chloride-pumping Rhodopsin

Phan LX, Chamorro VC, Martinez-Seara H, Crain J, Sansom MSP, Tucker SJ

March 2023 | Journal article | Biophysical Journal | Read

A Special Issue of Essays in Biochemistry on Structural Mass Spectrometry

Britt HM, Beveridge R , Calabrese AN

March 2023 | Journal article | Essays Biochem | Read

Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

El-Baba TJ, Lutomski CA, Burnap SA, Bolla JR, Baker LA, Baldwin AJ, Struwe WB, Robinson CV

March 2023 | Journal article | JACS | Read

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays

Tyrrell BE, Kumar A, Gangadharan B, Alonzi D, Brun J, Hill M, Bharucha T, Bosworth A, Graham V, Dowall S, Miller JL, Zitzmann N

March 2023 | Journal article | Pathogens | Read

A Quantitative Description for Optical Mass Measurement of Single Biomolecules

Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P

March 2023 | Journal article | bioRxiv | Read

Post-translational Proteomics Platform Identifies Neurite Outgrowth Impairments in Parkinson's Disease GBA-N370S Dopamine Neurons 

Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R

March 2023 | Journal article | Cell Reports | Read

In Conversation with Carol Robinson 

Dhillon P, Robinson C.

March 2023 | Journal article | Febs | Read

Effects of Clozapine-N-oxide and Compound 21 on Sleep in Laboratory Mice 

Traut J, Mengual JP, Meijer EJ, McKillop LE, Alfonsa H, Hoerder-Suabedissen A, Song SH, Fehér KD, Riemann D, Molnar Z, Akerman CJ, Vyazovskiy VV, Krone LB

March 2023 | Journal article | eLife | Read

Rationalizing the Optimization of Detergents for Membrane Protein Purification

Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV

March 2023 | Journal article | Chemistry | Read

Impaired Dopamine Release in Parkinson’s Disease

Cramb KML,  Beccano-Kelly D,  Cragg SJ, Wade-Martins R

March 2023 | Journal article | Brain | Read

Mass Spectrometry of Intact Membrane Proteins: Shifting Towards a More Native-like Context

Oluwole A, Shutin D, Bolla JR

February 2023 | Journal article | Essays in Biochemistry | Read

Posttranslational, Site-directed Photochemical Fluorine Editing of Protein Sidechains to Probe Residue Oxidation State via ¹⁹F-nuclear Magnetic Resonance 

Isenegger PG, Josephson B, Gaunt B, Davy MJ, Gouverneur V, Baldwin AJ, Davis BG

February 2023 | Journal article | Nature Protocols | Read

Detection of Neuronal OFF Periods as Low Amplitude Neural Activity Segments 

Harding CD, Guillaumin MCC, Krone LB, Kahn MC, Blanco-Duque C, Mikutta C, Vyazovskiy VV

February 2023 | Journal article | BMC Neuroscience | Read

HS 3D-SeboSkin Model Enables the Preclinical Exploration of Therapeutic Candidates for Hidradenitis Suppurativa/Acne Inversa 

Cramb KML,  Beccano-Kelly D,  Cragg SJ, Wade-Martins R

February 2023 | Journal article | Pharmaceutics | Read

Functional Integrity of Visual Coding Following Advanced Photoreceptor Degeneration

Rodgers J, Hughes S, Lindner M, Allen AE, Ebrahimi AS, Storchi R, Peirson SN, Lucas RJ, Hankins MW

January 2023 | Journal article | Current Biology | Read

Efficiently Computing the Uhlmann Fidelity for Density Matrices

Baldwin AJ and Jones JA

January 2023 | Journal article | Physical Review A | Read

Unconventional Secretion of alpha-synuclein Mediated by Palmitoylated DNAJC5 Oligomers

Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R 

January 2023 | Journal article | eLife | Read

A Dual Detergent Strategy to Capture a Bacterial Outer Membrane Proteome in Peptidiscs for Characterization by Mass Spectrometry and Binding Assays

Young JW, Zhao ZY, Wason IS, van Hoa FD 

December 2022 | Journal article | Journal of Proteome Research  | Read

“Paradoxical wakefulness” Induced by Psychedelic 5-methoxy-N, N-dimethyltryptamine in Mice

JB Bréant BJB, Mengual JP, Bannerman DM, Sharp T, Vyazovskiy VV

December 2022 | Journal article | Progress in Brain Research | Read

Coalescing Aptamers and Liquid-Crystals for Sensing Applications

Kulabhusana PK, Ray R, Ramachandra SG, Srinivasulu M, Hariharan A, Balaji K, Mani NK

December 2022 | Journal article | Microchemical Journal | Read

Neurons Derived from Individual Early Alzheimer's Disease Patients Reflect Their Clinical Vulnerability

Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R

November 2022 | Journal article | Brain Communications | Read

Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System

Bespalova M, Öz R, Westerlund F, Krishnan M

November 2022 | Journal article | Langmuir | Read

Glycosylated Clusterin Species Facilitate Aβ Toxicity in Human Neurons

Foster EM, Fernandes M, Dangla-Valls A, Hublitz P, Pangalos M, Lovestone S, Ribe EM, Buckley NJ

November 2022 | Journal article | Scientific Reports | Read

Expansion and Neofunctionalization of Actinoporin-like Genes in Mediterranean Mussel (Mytilus galloprovincialis)

Koritnik N,  Gerdol M,  Šolinc G,  Švigelj T,  Caserman S, Merzel F, Holden E,  Benesch JLP,  Trenti F, Guella G,  Pallavicini A,  Modica MV, Podobnik M, Anderluh G

November 2022 | Journal article | Genome Biology and Evolution | Read

Anionic Lipids Unlock the Gates of Select Ion Channels in the Pacemaker Family

Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM

November 2022 | Journal article | Nature Structural & Molecular Biology | Read

Mass Spectrometry Captures Biased Signalling and Allosteric Modulation of a G-Protein-Coupled Receptor

Yen HY, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, Gherbi K, Hopper JTS, Charlton S, Politis A, Sansom MSP, Jazayeri A, Robinson CV

November 2022 | Journal article | Nature Chemistry | Read

Native Top-Down Mass Spectrometry Reveals a Role for Interfacial Glycans on Therapeutic Cytokine and Hormone Assemblies

Wu D and Robinson CV

November 2022 | Journal article | Angewandte Chemie-International Edition | Read

CryoEM of Endogenous Mammalian V-ATPase Interacting with the TLDc Protein mEAK-7

Tan YZ , Abbas YM, Wu JZ, Wu D, Keon KA, Hesketh GG, Bueler SA, Gingras AC, Robinson CV, Grinstein S, Rubinstein JL 

November 2022 | Journal article | Life Science Alliance | Read

Lipids Mediate Supramolecular Outer Membrane Protein Assembly in Bacteria

Webby MN, Oluwole AO, Pedebos C, Inns PG, Olerinyova A, Prakaash D, Housden NG, Benn G, Sun D, Hoogenbook BW, Kukura P, Mohammed S, Robinson CV, Khalid S, Kleanthous C

November 2022 | Journal article | Science Advances | Read

When is a hydrophobic gate not a hydrophobic gate?

Seiferth D, Biggin PC, Tucker SJ

October 2022 | Journal article | Journal of General Physiology | Read

Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

Ndunge OBA, Kilian N, Salman MM

October 2022 | Journal article | Advanced Science | Read

GPC3-Unc5 Receptor Complex Structure and Role in Cell Migration

Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E

October 2022 | Journal article | Cell | Read

GPR97 Triggers Inflammatory Processes in Human Neutrophils via a Macromolecular Complex Upstream of PAR2 Activation

Chu TY, Zheng-Gérard C, Huang KY, Chang YC, Chen YW, I KY, Lo YL, Chiang NY, Chen HY, Stacey M, Gordon S, Tseng WY, Sun CY, Wu YM, Pan YS, Huang CH, Lin CY, Chen TC, El Omari K, Antonelou M, Henderson SR, Salama A, Seiradake E & Lin HH

October 2022 | Journal article | Nature Communications | Read

Neurons Derived from Individual Early Alzheimer’s Disease Patients Reflect Their Clinical Vulnerability

Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R

October 2022 | Journal article | Brain Communications | Read

Mass Photometry Reveals SARS-CoV-2 Spike Stabilisation to Impede ACE2 Binding Through Altered Conformational Dynamics

Burnap SA, Struwe W

October 2022 | Journal article | Chemical Communications | Read

Gain-of-function Mutations in KCNK3 Cause a Developmental Disorder with Sleep Apnea

Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ.

October 2022 | Journal article | Nature Genetics | Read

Repressor Element 1-Silencing Transcription Factor Deficiency Yields Profound Hearing Loss Through K(v)7.4 Channel Upsurge in Auditory Neurons and Hair Cells

Zhang H, Li H, Lu M, Wang S, Ma X, Wang F, Liu J, Li X, Yang H, Zhang F, Shen H, Buckley NJ, Gamper N, Yamoah EN, Lv P

September 2022 | Journal article | eLife | Read

Far-Field Electrostatic Signatures of Macromolecular 3D Conformation

Kloes G, Bennett TJD, Chapet-Batlle A, Behjatian A, Turberfield AJ, Krishnan M 

September 2022 | Journal article | Nano Letters | Read

Purkinje Cell Patterning—Insights from Single-Cell Sequencing

Apsley EJ, Becker EBE

September 2022 | Journal article | Cells | Read

Structure of the Malaria Vaccine Candidate Pfs48/45 and its Recognition by Transmission Blocking Antibodies

Ko KT, Lennartz F, Mekhaiel D, Guloglu B, Marini A, Deuker DJ, Long CA, Jore MM, Miura K, Biswas S, Higgins MK

September 2022 | Journal article | Nature Communications | Read

Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor

Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M

September 2022 | Journal article | Nature Communications | Read

Multiplex Lateral Flow Assay and the Sample Preparation Method for the Simultaneous Detection of Three Marine Toxins

Mills C, Dillon MJ, Kulabhusan PK, Senovilla-Herrero D, Campbell K

September 2022 | Journal article | Environmental Science & Technology | Read

Direct Observation of the Molecular Mechanism Underlying Protein Polymerization

Hundt N, Cole D, Hantke MF, Miller JJ, Struwe WB, Kukura P

August 2022 | Journal article | Science Advances | Read

Structural Basis for Proton Coupled Cystine Transport by Cystinosin

Löbel M, Salphati SP, El Omari K, Wagner A, Tucker SJ, Parker JL, Newstead S

August 2022 | Journal article | Nature Communications | Read

Re-examining Extreme Sleep Duration in Bats: Implications for Sleep Phylogeny, Ecology, and Function

Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV

August 2022 | Journal article | Sleep | Read

A new class of biological ion-driven rotary molecular motors with 5:2 symmetry

Rieu M, Krutyholowa R, Taylor NMI, Berry RM

August 2022 | Journal article | Frontiers in Microbiology | Read

Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor

Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M

August 2022 | Journal article | Nature Communications | Read

Human iPSC Co-culture Model to Investigate the Interaction between Microglia and Motor Neurons

Vahsen BF, Gray E, Candalija A, Cramb KML, Scaber J, Dafinca R, Katsikoudi A, Xu Y, Farrimond L, Wade-Martins R, James WS, Turner MR, Cowley SA, Talbot K

July 2022 | Journal article | Scientific Reports | Read

Pathogen-sugar Interactions Revealed by Universal Saturation Transfer Analysis.

Buchanan CJ, Baldwin A, et al.

July 2022 | Journal article | Science | Read

Influence of Effective Polarization on Ion and Water Interactions within a Biomimetic Nanopore

Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ 

June 2022 | Journal article | Biophysical Journal | Read

No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort

Tamm S, Harmer CJ, Schiel J, Holub F, Rutter MK, Spiegelhalder K, Kyle SD

June 2022 | Journal article | The American Journal of Psychiatry | Read

Patched 1 Regulates Smoothened by Controlling Sterol Binding to its Extracellular Cysteine-rich Domain

Kinnebrew M, Woolley RE, Ansell, TB, Byrne, EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey D, Siebold C, Rohatgi R

June 2022 | Journal article | Science Advances | Read

Cryo-EM Structures of Pentameric Autoinducer-2 Exporter from Escherichia Coli Reveal its Transport Mechanism

Khera R, Mehdipour AR, Bolla JR, Kahnt J, Welsch S, Ermler U, Muenke C, Robinson CV, Hummer G, Xie H

June 2022 | Journal article | The EMBO Journal | Read

Characterising Biomolecular Interactions and Dynamics with Mass Photometry.

Asor R and Kukura P

June 2022 | Journal article | Current Opinion in Chemical Biology | Read

Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.

Carlyle BC, Kitchen RR, Mattingly Z, Celia AM, Trombetta BA, Das S, Hyman BT, Kivisäkk P, Arnold SE

June 2022 | Journal article | Frontiers in Neurology | Read

Evidence‐informed is not enough: digital therapeutics also need to be evidence‐based.

Espie CA, Firth J, Torous J

June 2022 | Journal article | World Psychiatry | Read

Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors.

Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem JU, Schofield CJ 

May 2022 | Journal article | Proceedings of the National Academy of Sciences of the United States of America | Read

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S, Beccano-Kelly DA, Talbot K, Llana OC, Wade-Martins R 

May 2022 | Journal article | Scientific Reports | Read

Multivalent interactions essential for lentiviral integrase function.

Ballandras-Colas A,  Chivukula V, Gruszka DT, Shan ZL, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P

May 2022 | Journal article | Nature Communications | Read

Ion currents through Kir potassium channels are gated by anionic lipids.

Jin RT, He ST, Black KA, Clarke OB, Wu D, Bolla JR, Johnson P, Periasamy A, Wardak A, Czabotar P, Colman PM, Robinson CV, Laver D, Smith BJ, Gulbis JM 

January 2022 | Journal article | Nature Communications | Read

Recent breakthroughs and future directions in drugging aquaporins.

Salman MM, Kitchen P, Yool AJ, Bill RM

January 2022 | Journal article | Trends in Pharmacological Sciences | Read

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development.

Jiang C, Fu Y, Liu G, Shu B, Davis J, Tofaris GK

December 2021 | Journal article | Nano-Micro Letters | Read

Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation.

Prince JP, Bolla JR, Fisher GLM, Mäkelä J, Fournier M, Robinson CV, Arciszewska LK, Sherratt DJ

November 2021 | Journal article | Nature Communications | Read

Single molecule mass photometry reveals the dynamic oligomerization of human and plant peroxiredoxins.

Liebthal M, Kushwah MS, Kukura P, Dietz K-J

November 2021 | Journal article | iScience | Read

Effects of ionic strength on gating and permeation of TREK-2 K2P channels

Conrad LJ, Proks P, Tucker SJ

October 2021 | Journal article | Plos One | Read

Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport.

Bolla JR, Fiorentino F, Robinson CV

October 2021 | Journal article | Current Opinion in Structural Biology | Read

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target

Adams O, Deme JC, Parker JL, Fowler PW, Lea SM, Newstead S

October 2021 | Journal article | Structure | Read

Structural Basis for Silicic Acid Uptake by Higher Plants.

van den Berg B, Pedebos C, Bolla JR, Robinson CV, Baslé A, Khalid S

September 2021 | Journal article | Journal of Molecular Biology | Read

Parker JL, Deme JC, Wu Z, Kuteyi G, Huo J, Owens RJ, Biggin PC, Lea SM, Newstead S

August 2021 | Journal article | Science Advances | Read

The molecular basis of regulation of bacterial capsule assembly by Wzc.

Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH

July 2021 | Journal article | Nature Communications | Read

Structural basis of antifolate recognition and transport by PCFT.

Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S

July 2021 | Journal article | Nature | Read

Adams O, Deme JC, Parker JL, CRyPTIC Consortium, Fowler PW, Lea SM, Newstead S

June 2021 | Journal article | Structure | Read

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons.

Tanudjojo B, Shaikh SS, Fenyi A, Bousset L, Agarwal D, Marsh J, Zois C, Heman-Ackah S, Fischer R, Sims D, Melki R, Tofaris GK

June 2021 | Journal article | Nature Communications | Read

The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase.

Kaur H, Jakob RP, Marzinek JK, Green R, Imai Y, Bolla JR, Agustoni E, Robinson CV, Bond PJ, Lewis K, Maier T, Hiller S

May 2021 | Journal article | Nature | Read