Rationalizing the Optimization of Detergents for Membrane Protein Purification.

Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV

May 2023 | Journal article | Chemistry Europe | Read

Methodological Considerations in Neuronal Extracellular Vesicle Isolation for α-synuclein Biomarkers.

Yan S, Jiang C, Davis JJ, Tofaris GK

May 2023 | Journal article | Brain | Read

Brain Stimulation Techniques as Novel Treatment Options for Insomnia: A Systematic Review.

Krone LB, Fehér KD, Rivero T, Omlin X

May 2023 | Journal article | Journal of Sleep Research | Read

Single-molecule FRET for Virology: 20 Years of Insight into Protein Structure and Dynamics.

Groves D, Hepp C, Kapanidis AN, Robb NC

May 2023 | Journal article | Quarterly Reviews of Biophysics | Read

Deep Proteomics Network and Machine Learning Analysis of Human Cerebrospinal Fluid in Japanese Encephalitis Virus Infection.

Bharucha T, Gangadharan B, Kumar A, Myall AC, Ayhan N, Pastorino B, Chanthongthip A, Vongsouvath M, Mayxay M, Sengvilaipaseuth O, Phonemixay O, Rattanavong S, O'Brien DP, Vendrell I, Fischer R, Kessler B, Turtle L, de Lamballerie X, Dubot-Pérès A, Newton PN, Zitzmann N, SEAe Consortium

May 2023 | Journal article | Journal of Proteome Research | Read

α-Synuclein Fibril and Synaptic Vesicle Interactions Lead to Vesicle Destruction and Increased Lipid-Associated Fibril Uptake into iPSC-derived Neurons.

Stephens AD, Villegas AF, Chung CW, Vanderpoorten O, Pinotsi D, Mela I, Ward E, McCoy TM, Cubitt R, Routh AF, Kaminski CF, Kaminski Schierle GS

May 2023 | Journal article | Communications Biology | Read

A Modular RNA Delivery System Comprising Spherical Nucleic Acids Built on Endosome-escaping Polymeric Nanoparticles.

Garcia-Guerra A, Ellerington R, Gaitzsch J, Bath J, Kye M, Varela MA, Battaglia G, Wood MJA, Manzano R, Rinaldi C, Turberfield AJ.

May 2023 | Journal article | Nanoscale Advances | Read

Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson's Disease Diagnostics.

Sharafeldin M, Yan S, Jiang C, Tofaris GK, Davis JJ

May 2023 | Journal article | Analytical Chemistry | Read

Advantages of Routine Next Generation Sequencing Over Standard Genetic Testing in the ALS Clinic.

Scaber J, Thompson AG, Farrimond L, Feneberg E, Proudfoot M, Ossher L, Turner MR, Talbot K

May 2023 | Journal article | Europen Journal of Neurology | Read

G Protein-Coupled Receptor Pharmacology-Insights from Mass Spectrometry

Yen HY, Jazayeri A, Robinson CV

May 2023 | Journal article | Pharmacological Reviews | Read

Reconfigurable Self-Assembled DNA Devices

Benson E, Bath J

April 2023 | Journal article | Science Robotics | Read

Bleaching-resistant, Near-continuous Single-molecule Fluorescence and FRET Based on Fluorogenic and Transient DNA Binding

Kümmerlin M, Mazumder A, Kapanidis AN

April 2023 | Journal article | Chemphyschem | Read

Reliability and Accuracy of Single-molecule FRET Studies for Characterization of Structural Dynamics and Distances in Proteins

Agam G, Gebhardt C, Popara M, Mächtel R, Folz J, Ambrose B, Chamachi N, Chung SY, Craggs TD, de Boer M, Grohmann D, Ha T, Hartmann A, Hendrix J, Hirschfeld V, Hübner CG, Hugel T, Kammerer D, Kang HS, Kapanidis AN, Krainer G, Kramm K, Lemke EA, Lerner E, Margeat E, Martens K, Michaelis J, Mitra J, Moya Muñoz GG, Quast RB, Robb NC, Sattler M, Schlierf M, Schneider J, Schröder T, Sefer A, Tan PS, Thurn J, Tinnefeld P, van Noort J, Weiss S, Wendler N, Zijlstra N, Barth A, Seidel CAM, Lamb DC, Cordes T

April 2023 | Journal article | Nature Methods | Read

Shapeshifting Bullvalene-linked Vancomycin Dimers as Effective Antibiotics Against Multidrug-resistant Gram-positive Bacteria

Ottonello A, Wyllie JA, Yahiaoui O, Sun S, Koelln RA, Homer JA, Johnson RM, Murray E, Williams P, Bolla JR, Robinson CV, Fallon T, Soares da Costa TP, Moses JE

April 2023 | Journal article | PNAS | Read

Fortuitously Compatible Protein Surfaces Primed Allosteric Control in Cyanobacterial Photoprotection

Steube N, Moldenhauer M, Weiland P, Saman D, Kilb A, Rojas AAR, Garg SG, Schindler D, Graumann PL, Benesch JLP, Bange G, Friedrich T, Hochberg GKA

April 2023 | Journal article | Nature Ecology & Evolution | Read

Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer's Disease

Quinn JP, Ethier EC, Novielli A, Malone A, Ramirez CE, Salloum L, Trombetta BA, Kivisäkk P, Bremang M, Selzer S, Fournier M, Das S, Xing Y, Arnold SE, Carlyle BC

March 2023 | Journal article | Journal of the American Society for Mass Spectrometry | Read

An in-solution Snapshot of SARS-COV-2 Main Protease Maturation Process and Inhibition

Noske GD, Song Y, Fernandes RS, Chalk R, Elmassoudi H, Koekemoer L, Owen CD, El-Baba TJ, Robinson CV, COVID Moonshot Consortium, Oliva G, Godoy AS 

March 2023 | Journal article | Nature Communications | Read

Influence of Electronic Polarization on the Binding of Anions to a Chloride-pumping Rhodopsin

Phan LX, Chamorro VC, Martinez-Seara H, Crain J, Sansom MSP, Tucker SJ

March 2023 | Journal article | Biophysical Journal | Read

A Special Issue of Essays in Biochemistry on Structural Mass Spectrometry

Britt HM, Beveridge R , Calabrese AN

March 2023 | Journal article | Essays Biochem | Read

Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry

El-Baba TJ, Lutomski CA, Burnap SA, Bolla JR, Baker LA, Baldwin AJ, Struwe WB, Robinson CV

March 2023 | Journal article | JACS | Read

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays

Tyrrell BE, Kumar A, Gangadharan B, Alonzi D, Brun J, Hill M, Bharucha T, Bosworth A, Graham V, Dowall S, Miller JL, Zitzmann N

March 2023 | Journal article | Pathogens | Read

A Quantitative Description for Optical Mass Measurement of Single Biomolecules

Becker J, Peters JS, Crooks I, Helmi S, Synakewicz M, Schuler B, Kukura P

March 2023 | Journal article | bioRxiv | Read

Post-translational Proteomics Platform Identifies Neurite Outgrowth Impairments in Parkinson's Disease GBA-N370S Dopamine Neurons 

Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R

March 2023 | Journal article | Cell Reports | Read

In Conversation with Carol Robinson 

Dhillon P, Robinson C.

March 2023 | Journal article | Febs | Read

Effects of Clozapine-N-oxide and Compound 21 on Sleep in Laboratory Mice 

Traut J, Mengual JP, Meijer EJ, McKillop LE, Alfonsa H, Hoerder-Suabedissen A, Song SH, Fehér KD, Riemann D, Molnar Z, Akerman CJ, Vyazovskiy VV, Krone LB

March 2023 | Journal article | eLife | Read

Rationalizing the Optimization of Detergents for Membrane Protein Purification

Urner LH, Junge F, Fiorentino F, El-Baba TJ, Shutin D, Nölte G, Haag R, Robinson CV

March 2023 | Journal article | Chemistry | Read

Impaired Dopamine Release in Parkinson’s Disease

Cramb KML,  Beccano-Kelly D,  Cragg SJ, Wade-Martins R

March 2023 | Journal article | Brain | Read

Mass Spectrometry of Intact Membrane Proteins: Shifting Towards a More Native-like Context

Oluwole A, Shutin D, Bolla JR

February 2023 | Journal article | Essays in Biochemistry | Read

Posttranslational, Site-directed Photochemical Fluorine Editing of Protein Sidechains to Probe Residue Oxidation State via 19F-nuclear Magnetic Resonance 

Isenegger PG, Josephson B, Gaunt B, Davy MJ, Gouverneur V, Baldwin AJ, Davis BG

February 2023 | Journal article | Nature Protocols | Read

Detection of Neuronal OFF Periods as Low Amplitude Neural Activity Segments 

Harding CD, Guillaumin MCC, Krone LB, Kahn MC, Blanco-Duque C, Mikutta C, Vyazovskiy VV

February 2023 | Journal article | BMC Neuroscience | Read

HS 3D-SeboSkin Model Enables the Preclinical Exploration of Therapeutic Candidates for Hidradenitis Suppurativa/Acne Inversa 

Cramb KML,  Beccano-Kelly D,  Cragg SJ, Wade-Martins R

February 2023 | Journal article | Pharmaceutics | Read

Functional Integrity of Visual Coding Following Advanced Photoreceptor Degeneration

Rodgers J, Hughes S, Lindner M, Allen AE, Ebrahimi AS, Storchi R, Peirson SN, Lucas RJ, Hankins MW

January 2023 | Journal article | Current Biology | Read

Efficiently Computing the Uhlmann Fidelity for Density Matrices

Baldwin AJ and Jones JA

January 2023 | Journal article | Physical Review A | Read

Unconventional Secretion of alpha-synuclein Mediated by Palmitoylated DNAJC5 Oligomers

Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R 

January 2023 | Journal article | eLife | Read



A Dual Detergent Strategy to Capture a Bacterial Outer Membrane Proteome in Peptidiscs for Characterization by Mass Spectrometry and Binding Assays

Young JW, Zhao ZY, Wason IS, van Hoa FD 

December 2022 | Journal article | Journal of Proteome Research  | Read

“Paradoxical wakefulness” Induced by Psychedelic 5-methoxy-N, N-dimethyltryptamine in Mice

JB Bréant BJB, Mengual JP, Bannerman DM, Sharp T, Vyazovskiy VV

December 2022 | Journal article | Progress in Brain Research | Read

Coalescing Aptamers and Liquid-Crystals for Sensing Applications

Kulabhusana PK, Ray R, Ramachandra SG, Srinivasulu M, Hariharan A, Balaji K, Mani NK

December 2022 | Journal article | Microchemical Journal | Read

Neurons Derived from Individual Early Alzheimer's Disease Patients Reflect Their Clinical Vulnerability

Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R

November 2022 | Journal article | Brain Communications | Read

Single-Molecule Trapping and Measurement in a Nanostructured Lipid Bilayer System

Bespalova M, Öz R, Westerlund F, Krishnan M

November 2022 | Journal article | Langmuir | Read

Glycosylated Clusterin Species Facilitate Aβ Toxicity in Human Neurons

Foster EM, Fernandes M, Dangla-Valls A, Hublitz P, Pangalos M, Lovestone S, Ribe EM, Buckley NJ

November 2022 | Journal article | Scientific Reports | Read

Expansion and Neofunctionalization of Actinoporin-like Genes in Mediterranean Mussel (Mytilus galloprovincialis)

Koritnik N,  Gerdol M,  Šolinc G,  Švigelj T,  Caserman S, Merzel F, Holden E,  Benesch JLP,  Trenti F, Guella G,  Pallavicini A,  Modica MV, Podobnik M, Anderluh G

November 2022 | Journal article | Genome Biology and Evolution | Read

Anionic Lipids Unlock the Gates of Select Ion Channels in the Pacemaker Family

Schmidpeter PAM, Wu D, Rheinberger J, Riegelhaupt PM, Tang H, Robinson CV, Nimigean CM

November 2022 | Journal article | Nature Structural & Molecular Biology | Read

Mass Spectrometry Captures Biased Signalling and Allosteric Modulation of a G-Protein-Coupled Receptor

Yen HY, Liko I, Song W, Kapoor P, Almeida F, Toporowska J, Gherbi K, Hopper JTS, Charlton S, Politis A, Sansom MSP, Jazayeri A, Robinson CV

November 2022 | Journal article | Nature Chemistry | Read

Native Top-Down Mass Spectrometry Reveals a Role for Interfacial Glycans on Therapeutic Cytokine and Hormone Assemblies

Wu D and Robinson CV

November 2022 | Journal article | Angewandte Chemie-International Edition | Read

CryoEM of Endogenous Mammalian V-ATPase Interacting with the TLDc Protein mEAK-7

Tan YZ , Abbas YM, Wu JZ, Wu D, Keon KA, Hesketh GG, Bueler SA, Gingras AC, Robinson CV, Grinstein S, Rubinstein JL 

November 2022 | Journal article | Life Science Alliance | Read

Lipids Mediate Supramolecular Outer Membrane Protein Assembly in Bacteria

Webby MN, Oluwole AO, Pedebos C, Inns PG, Olerinyova A, Prakaash D, Housden NG, Benn G, Sun D, Hoogenbook BW, Kukura P, Mohammed S, Robinson CV, Khalid S, Kleanthous C

November 2022 | Journal article | Science Advances | Read

When is a hydrophobic gate not a hydrophobic gate?

Seiferth D, Biggin PC, Tucker SJ

October 2022 | Journal article | Journal of General Physiology | Read

Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

Ndunge OBA, Kilian N, Salman MM

October 2022 | Journal article | Advanced Science | Read

GPC3-Unc5 Receptor Complex Structure and Role in Cell Migration

Akkermans O, Delloye-Bourgeois C, Peregrina C, Carrasquero-Ordaz M, Kokolaki M, Berbeira-Santana M, Chavent M, Reynaud F, Raj R, Agirre J, Aksu M, White ES, Lowe E, Ben Amar D, Zaballa S, Huo J, Pakos I, McCubbin PTN, Comoletti D, Owens RJ, Robinson CV, Castellani V, Del Toro D, Seiradake E

October 2022 | Journal article | Cell | Read

GPR97 Triggers Inflammatory Processes in Human Neutrophils via a Macromolecular Complex Upstream of PAR2 Activation

Chu TY, Zheng-Gérard C, Huang KY, Chang YC, Chen YW, I KY, Lo YL, Chiang NY, Chen HY, Stacey M, Gordon S, Tseng WY, Sun CY, Wu YM, Pan YS, Huang CH, Lin CY, Chen TC, El Omari K, Antonelou M, Henderson SR, Salama A, Seiradake E & Lin HH

October 2022 | Journal article | Nature Communications | Read

Neurons Derived from Individual Early Alzheimer’s Disease Patients Reflect Their Clinical Vulnerability

Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, Gunn RN, Kocagoncu E, Lawson J, Malhotra PA, Ridha BH, Rowe JB, Thomas AJ, Zamboni G, Buckley NJ, Cader ZM, Lovestone S, Wade-Martins R

October 2022 | Journal article | Brain Communications | Read

Mass Photometry Reveals SARS-CoV-2 Spike Stabilisation to Impede ACE2 Binding Through Altered Conformational Dynamics

Burnap SA, Struwe W

October 2022 | Journal article | Chemical Communications | Read

Gain-of-function Mutations in KCNK3 Cause a Developmental Disorder with Sleep Apnea

Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ.

October 2022 | Journal article | Nature Genetics | Read

Repressor Element 1-Silencing Transcription Factor Deficiency Yields Profound Hearing Loss Through K(v)7.4 Channel Upsurge in Auditory Neurons and Hair Cells

Zhang H, Li H, Lu M, Wang S, Ma X, Wang F, Liu J, Li X, Yang H, Zhang F, Shen H, Buckley NJ, Gamper N, Yamoah EN, Lv P

September 2022 | Journal article | eLife | Read

Far-Field Electrostatic Signatures of Macromolecular 3D Conformation

Kloes G, Bennett TJD, Chapet-Batlle A, Behjatian A, Turberfield AJ, Krishnan M 

September 2022 | Journal article | Nano Letters | Read

Purkinje Cell Patterning—Insights from Single-Cell Sequencing

Apsley EJ, Becker EBE

September 2022 | Journal article | Cells | Read

Structure of the Malaria Vaccine Candidate Pfs48/45 and its Recognition by Transmission Blocking Antibodies

Ko KT, Lennartz F, Mekhaiel D, Guloglu B, Marini A, Deuker DJ, Long CA, Jore MM, Miura K, Biswas S, Higgins MK

September 2022 | Journal article | Nature Communications | Read

Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor

Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M

September 2022 | Journal article | Nature Communications | Read

Multiplex Lateral Flow Assay and the Sample Preparation Method for the Simultaneous Detection of Three Marine Toxins

Mills C, Dillon MJ, Kulabhusan PK, Senovilla-Herrero D, Campbell K

September 2022 | Journal article | Environmental Science & Technology | Read


Direct Observation of the Molecular Mechanism Underlying Protein Polymerization

Hundt N, Cole D, Hantke MF, Miller JJ, Struwe WB, Kukura P

August 2022 | Journal article | Science Advances | Read

Structural Basis for Proton Coupled Cystine Transport by Cystinosin

Löbel M, Salphati SP, El Omari K, Wagner A, Tucker SJ, Parker JL, Newstead S

August 2022 | Journal article | Nature Communications | Read


Re-examining Extreme Sleep Duration in Bats: Implications for Sleep Phylogeny, Ecology, and Function

Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV

August 2022 | Journal article | Sleep | Read

A new class of biological ion-driven rotary molecular motors with 5:2 symmetry

Rieu M, Krutyholowa R, Taylor NMI, Berry RM

August 2022 | Journal article | Frontiers in Microbiology | Read

Invariant Surface Glycoprotein 65 of Trypanosoma Brucei is a Complement C3 Receptor

Macleod OJS, Cook AD, Webb H, Crow M, Burns R, Redpath M, Seisenberger S, Trevor CE, Peacock L, Schwede A, Kimblin N, Francisco AF, Pepperl J, Rust S, Voorheis P, Gibson W, Taylor MC, Higgins MK, Carrington M

August 2022 | Journal article | Nature Communications | Read

Human iPSC Co-culture Model to Investigate the Interaction between Microglia and Motor Neurons

Vahsen BF, Gray E, Candalija A, Cramb KML, Scaber J, Dafinca R, Katsikoudi A, Xu Y, Farrimond L, Wade-Martins R, James WS, Turner MR, Cowley SA, Talbot K

July 2022 | Journal article | Scientific Reports | Read

Pathogen-sugar Interactions Revealed by Universal Saturation Transfer Analysis.

Buchanan CJ, Baldwin A, et al.

July 2022 | Journal article | Science | Read

Influence of Effective Polarization on Ion and Water Interactions within a Biomimetic Nanopore

Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ 

June 2022 | Journal article | Biophysical Journal | Read

No Association Between Amygdala Responses to Negative Faces and Depressive Symptoms: Cross-Sectional Data from 28,638 Individuals in the UK Biobank Cohort

Tamm S, Harmer CJ, Schiel J, Holub F, Rutter MK, Spiegelhalder K, Kyle SD

June 2022 | Journal article | The American Journal of Psychiatry | Read

Patched 1 Regulates Smoothened by Controlling Sterol Binding to its Extracellular Cysteine-rich Domain

Kinnebrew M, Woolley RE, Ansell, TB, Byrne, EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey D, Siebold C, Rohatgi R

June 2022 | Journal article | Science Advances | Read

Cryo-EM Structures of Pentameric Autoinducer-2 Exporter from Escherichia Coli Reveal its Transport Mechanism

Khera R, Mehdipour AR, Bolla JR, Kahnt J, Welsch S, Ermler U, Muenke C, Robinson CV, Hummer G, Xie H

June 2022 | Journal article | The EMBO Journal | Read

Characterising Biomolecular Interactions and Dynamics with Mass Photometry.

Asor R and Kukura P

June 2022 | Journal article | Current Opinion in Chemical Biology | Read

Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease.

Carlyle BC, Kitchen RR, Mattingly Z, Celia AM, Trombetta BA, Das S, Hyman BT, Kivisäkk P, Arnold SE

June 2022 | Journal article | Frontiers in Neurology | Read

Evidence‐informed is not enough: digital therapeutics also need to be evidence‐based.

Espie CA, Firth J, Torous J

June 2022 | Journal article | World Psychiatry | Read

Studies on enmetazobactam clarify mechanisms of widely used beta-lactamase inhibitors.

Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem JU, Schofield CJ 

May 2022 | Journal article | Proceedings of the National Academy of Sciences of the United States of America | Read

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S, Beccano-Kelly DA, Talbot K, Llana OC, Wade-Martins R 

May 2022 | Journal article | Scientific Reports | Read

Multivalent interactions essential for lentiviral integrase function.

Ballandras-Colas A,  Chivukula V, Gruszka DT, Shan ZL, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov P

May 2022 | Journal article | Nature Communications | Read



Initiation and progression of alpha-synuclein pathology in Parkinson's disease.

Tofaris GK.

April 2022 | Journal article | Cellular and Molecular Life Sciences | Read

Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients.

Oluwole AO, Corey RA, Brown CM, Hernandez-Rocamora VM, Stansfeld PJ, Vollmer W, Bolla JR, Robinson CV

April 2022 | Journal article | Nature Communications | Read

Capturing a rhodopsin receptor signalling cascade across a native membrane.

Chen SY, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV 

April 2022 | Journal article | Nature | Read

Template-directed conjugation of heterogeneous oligonucleotides to a homobifunctional molecule for programmable supramolecular assembly.

Helmi S, Turberfield AJ 

March 2022 | Journal article | Nanoscale | Read

Re-examining extreme sleep duration in bats: implications for sleep phylogeny, ecology, and function.

Harding CD, Yovel Y, Peirson SN, Hackett TD, Vyazovskiy VV 

March 2022 | Journal article | Sleep | Read

Ion and water interactions with a biomimetic nanopore: molecular dynamics with effective polarization

Phan LX, Lynch CI, Crain J, Sansom MSP, Tucker SJ 

February 2022 | Journal article | Biophysical Journal | Read

An In Vivo Fluorescence Resonance Energy Transfer-Based Imaging Platform for Targeted Drug Discovery and Cancer Therapy.

Huang SG, Jiang C, Mughal MJ, Wang GY, Xing FQ

February 2022 | Journal article | Frontiers in Bioengineering and Biotechnology | Read

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.

Ragotte RJ, Pulido D, Lias AM, Quinkert D, Alanine DGW, Jamwal A, Davies H, Nacer A, Lowe ED, Grime G, Illingworth J, Donat, RF, Garman EF, Bowyer, PW, Higgins MK, Draper SJ

February 2022 | Journal article | Nature Communications | Read

Cryo-EM structure of human GPR158 receptor coupled to the RGS7-G beta 5 signaling complex.

Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu XY, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh AK, Martemyanov KA

January 2022 | Journal article | Science | Read

Ion currents through Kir potassium channels are gated by anionic lipids.

Jin RT, He ST, Black KA, Clarke OB, Wu D, Bolla JR, Johnson P, Periasamy A, Wardak A, Czabotar P, Colman PM, Robinson CV, Laver D, Smith BJ, Gulbis JM 

January 2022 | Journal article | Nature Communications | Read

Recent breakthroughs and future directions in drugging aquaporins.

Salman MM, Kitchen P, Yool AJ, Bill RM

January 2022 | Journal article | Trends in Pharmacological Sciences | Read

Molecular basis for redox control by the human cystine/glutamate antiporter system xc.

Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S

December 2021 | Journal article | Nature Communications | Read

Biallelic PI4KA variants cause neurological, intestinal and immunological disease

Salter CG, Cai Y, Lo B, Helman G, Taylor H, McCartney A, Leslie JS, Accogli A, Zara F, Traverso M, Fasham J, Lees JA, Ferla MP, Chioza BA, Wenger O, Scott E, Cross HE, Crawford J, Warshawsky I, Keisling M, Agamanolis D, Melver CW, Cox H, Elawad M, Marton T, Wakeling MN, Holzinger D, Tippelt S, Munteanu M, Valcheva D, Deal C, Van Meerbeke S, Vockley CW, Butte M, Acar U, van der Knaap MS, Korenke GC, Kotzaeridou U, Balla T, Simons C, Uhlig HH, Crosby AH, De Camilli P, Wolf NI, Baple EL

December 2021 | Journal article | Brain | Read

Break-ups and make-ups: DNA search and repair.

Lalande E, El Sayyed H

December 2021 | Journal article | Nature Reviews Microbiology | Read

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development.

Jiang C, Fu Y, Liu G, Shu B, Davis J, Tofaris GK

December 2021 | Journal article | Nano-Micro Letters | Read

Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation.

Prince JP, Bolla JR, Fisher GLM, Mäkelä J, Fournier M, Robinson CV, Arciszewska LK, Sherratt DJ

November 2021 | Journal article | Nature Communications | Read

Single molecule mass photometry reveals the dynamic oligomerization of human and plant peroxiredoxins.

Liebthal M, Kushwah MS, Kukura P, Dietz K-J

November 2021 | Journal article | iScience | Read

Effects of ionic strength on gating and permeation of TREK-2 K2P channels

Conrad LJ, Proks P, Tucker SJ

October 2021 | Journal article | Plos One | Read

Mass spectrometry informs the structure and dynamics of membrane proteins involved in lipid and drug transport.

Bolla JR, Fiorentino F, Robinson CV

October 2021 | Journal article | Current Opinion in Structural Biology | Read

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target

Adams O, Deme JC, Parker JL, Fowler PW, Lea SM, Newstead S

October 2021 | Journal article | Structure | Read

Structural Basis for Silicic Acid Uptake by Higher Plants.

van den Berg B, Pedebos C, Bolla JR, Robinson CV, Baslé A, Khalid S

September 2021 | Journal article | Journal of Molecular Biology | Read


Molecular basis for redox control by the human cystine/glutamate antiporter System xc-

Parker JL, Deme JC, Kolokouris D, Kuteyi G, Biggin PC, Lea SM, Newstead S

August 2021 | Journal article | Read

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals.

Parker JL, Deme JC, Wu Z, Kuteyi G, Huo J, Owens RJ, Biggin PC, Lea SM, Newstead S

August 2021 | Journal article | Science Advances | Read

The molecular basis of regulation of bacterial capsule assembly by Wzc.

Yang Y, Liu J, Clarke BR, Seidel L, Bolla JR, Ward PN, Zhang P, Robinson CV, Whitfield C, Naismith JH

July 2021 | Journal article | Nature Communications | Read

Structural basis of antifolate recognition and transport by PCFT.

Parker JL, Deme JC, Kuteyi G, Wu Z, Huo J, Goldman ID, Owens RJ, Biggin PC, Lea SM, Newstead S

July 2021 | Journal article | Nature | Read

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.

Adams O, Deme JC, Parker JL, CRyPTIC Consortium, Fowler PW, Lea SM, Newstead S

June 2021 | Journal article | Structure | Read

The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase.

Kaur H, Jakob RP, Marzinek JK, Green R, Imai Y, Bolla JR, Agustoni E, Robinson CV, Bond PJ, Lewis K, Maier T, Hiller S

May 2021 | Journal article | Nature | Read