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Architecture-Driven Quantitative Nanoscopy Maps Cytoskeleton Remodeling

Liu W, Yao Y, Meng J, Qian S, Han Y, Zhou L, Wang T, Chen Y, Chen L, Ye Z, Xu L, Zhang M, Qiu J, Han T, Liu X, Kuang C, Ding Z, Liu Z

October 2024 | Journal article | PNAS | Read


Structural Basis for Antibiotic Transport and Inhibition in PepT2

Parker JL, Deme JC, Lichtinger SM, Kuteyi G, Biggin PC, Lea SM, Newstead S

October 2024 | Journal article | Nature Communications | Read


Transfer Learning Bayesian Optimization for Competitor DNA Molecule Design for Use in Diagnostic Assays

Sedgwick R, Goertz JP, Stevens MM, Misener R, van der Wilk M

October 2024 | Journal article | Biotechnology and Bioengineering | Read


Hyperspectral Unmixing for Raman Spectroscopy via Physics-Constrained Autoencoders

Georgiev D, Fernández-Galiana Á, Vilms Pedersen S, Papadopoulos G, Xie R, Stevens MM, Barahona M

October 2024 | Journal article | PNAS | Read


Blood-Stage Malaria Vaccine Candidate RH5.1/Matrix-M in Healthy Tanzanian Adults and Children; An Open-Label, Non-Randomised, First-in-Human, Single-Centre, Phase 1b Trial

Silk SE, Kalinga WF, Salkeld J, Mtaka IM, Ahmed S, Milando F, Diouf A, Bundi CK, Balige N, Hassan O, Mkindi CG, Rwezaula S, Athumani T, Mswata S, Lilolime NS, Simon B, Msami H, Mohamed M, David DM, Mohammed L, Nyaulingo G, Mwalimu B, Juma O, Mwamlima TG, Sasamalo IA, Mkumbange RP, Kamage JJ, Barrett JR, King LDW, Hou MM, Pulido D, Carnrot C, Lawrie AM, Cowan RE, Nugent FL, Roberts R, Cho JS, Long CA, Nielsen CM, Miura K, Draper SJ, Olotu AI, Minassian AM

October 2024 | Journal article | Lancet Infectious Diseases | Read


Structure and Conformation Determine Gas-Phase Infrared Spectra of Detergents

Kirschbaum C, Greis K, Gewinner S, Schöllkopf W, Meijer G, von Helden G, Pagel K, Urner LH

October 2024 | Journal article | Chem Plus Chem | Read


A Bioorthogonal Precision Tool for Human N-Acetylglucosaminyltransferase V

Liu Y, Bineva-Todd G, Meek RW, Mazo L, Piniello B, Moroz O, Burnap SA, Begum N, Ohara A, Roustan C, Tomita S, Kjaer S, Polizzi K, Struwe WB, Rovira C, Davies GJ, Schumann B

October 2024 | Journal article | Journal of the American Chemical Society | Read


Oligomerization-Driven Avidity Correlates with SARS-CoV-2 Cellular Binding and Inhibition

Asor R, Olerinyova A, Burnap SA, Kushwah MS, Soltermann F, Rudden LSP, Hensen M, Vasiljevic S, Brun J, Hill M, Chang L, Dejnirattisai W, Supasa P, Mongkolsapaya J, Zhou D, Stuart DI, Screaton GR, Degiacomi MT, Zitzmann N, Benesch JLP, Struwe WB, Kukura P

October 2024 | Journal article | PNAS | Read


Lipopeptide Antibiotics Disrupt Interactions of Undecaprenyl Phosphate with UptA

Oluwole AO, Kalmankar NV, Guida M, Bennett JL, Poce G, Bolla JR, Robinson CV

October 2024 | Journal article | PNAS | Read


Rational Structure-Guided Design of a Blood Stage Malaria Vaccine Immunogen Presenting a Single Epitope from PfRH5

Harrison TE, Alam N, Farrell B, Quinkert D, Lias AM, King LDW, Barfod LK, Draper SJ, Campeotto I, Higgins MK

October 2024 | Journal article | EMBO Molecular Medicine | Read


Proteome Aggregation in Cells Derived from Amyotrophic Lateral Sclerosis Patients for Personalized Drug Evaluation

Pérez de la Lastra Aranda C, Tosat-Bitrián C, Porras G, Dafinca R, Muñoz-Torrero D, Talbot K, Martín-Requero Á, Martínez A, Palomo V

October 2024 | Journal article | ACS Chemical Neuroscience | Read


Rapid Identification of Bacterial Isolates Using Microfluidic Adaptive Channels and Multiplexed Fluorescence Microscopy

Chatzimichail S, Turner P, Feehily C, Farrar A, Crook D, Andersson M, Oakley S, Barrett L, El Sayyed H, Kyropoulos J, Nellåker C, Stoesser N, Kapanidis AN

October 2024 | Journal article | Lab on a Chip | Read


Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop

Qiu X, Chao K, Song S, Wang YQ, Chen YA, Rouse SL, Yen HY, Robinson CV

October 2024 | Journal article | Journal of the American Chemical Society | Read


Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo-PISA

Thanapongpibul C, Rifaie-Graham O, Ojansivu M, Najer A, Kim H, Bakker SE, Chami M, Peeler DJ, Liu C, Yeow J, Stevens MM

October 2024 | Journal article | Advanced Materials | Read


Glial Cells Undergo Rapid Changes Following Acute Chemogenetic Manipulation of Cortical Layer 5 Projection Neurons

Vadisiute A, Meijer E, Therpurakal RN, Mueller M, Szabó F, Messore F, Jursenas A, Bredemeyer O, Krone LB, Mann E, Vyazovskiy V, Hoerder-Suabedissen A, Molnár Z

October 2024 | Journal article | Communications Biology | Read


Bioactive Coatings on 3D Printed Scaffolds for Bone Regeneration: Use of Laponite® to Deliver BMP-2 in an Ovine Femoral Condyle Defect Model

Marshall KM, McLaren JS, Wojciechowski JP, Callens SJP, Echalier C, Kanczler JM, Rose FRAJ, Stevens MM, Dawson JI, Oreffo ROC

October 2024 | Journal article | Biomaterials Advances | Read


Vaccine-Induced Human Monoclonal Antibodies to PfRH5 Show Broadly Neutralizing Activity Against P. falciparum Clinical Isolates

Thiam LG, McHugh K, Ba A, Li R, Guo Y, Pouye MN, Cisse A, Pipini D, Diallo F, Sene SD, Patel SD, Thiam A, Sadio BD, Mbengue A, Vigan-Womas I, Sheng Z, Shapiro L, Draper SJ, Bei AK

October 2024 | Journal article | NPJ Vaccines | Read


Dynactin-1 Mediates Rescue of Impaired Axonal Transport due to Reduced Mitochondrial Bioenergetics in Amyotrophic Lateral Sclerosis Motor Neurons

Dafinca R, Tosat-Bitrian C, Carroll E, Vahsen BF, Gilbert-Jaramillo J, Scaber J, Feneberg E, Johnson E, Talbot K

October 2024 | Journal article | Brain Communications | Read


Considerations of Growth Factor and Material Use in Bone Tissue Engineering Using Biodegradable Scaffolds in Vitro and in Vivo

Marshall KM, Wojciechowski JP, Jayawarna V, Hasan A, Echalier C, Øvrebø Ø, Yang T, Zhou K, Kanczler JM, Mata A, Salmeron-Sanchez M, Stevens MM, Oreffo ROC

October 2024 | Journal article | Scientific Reports | Read


The PIK3CA Gene and its Pivotal Role in Tumor Tropism of Triple-Negative Breast Cancer

Mallick S, Duttaroy AK, Dutta S

October 2024 | Journal article | Translational Oncology | Read


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