Kavli Research & Enterprise Discussions (K.R.E.D)
Our Kavli Research and Enterprise Discussion (K.R.E.D) will be given by Adriaan Bax.
Adriaan (Ad) Bax is a Dutch-American molecular biophysicist. He was born in the Netherlands and conducted most of his PhD research under the mentorship of Ray Freeman at Oxford University. He currently is the Chief of the Section on Biophysical NMR Spectroscopy at the National Institutes of Health. Bax is a pioneer in the development of advanced nuclear magnetic resonance (NMR) experiments for the study of structure and dynamics of isotopically enriched proteins. Much of his recent work focuses on folding and misfolding of proteins, related to amyloid diseases. In 2002 he was elected a member of the United States National Academy of Sciences and in 2018 he was awarded the Welch Award in Chemistry.
Adriaan's talk is entitled "The increasing power of NMR in challenging structural biology"
The abstract is below.
Over the past 40 years, NMR spectroscopy has expanded from a labor-intensive method for determining structures of small proteins to a versatile method for probing a vast array of functionally critical biological processes. With the emergence of powerful new computational and structural technologies, including AlphaFold and cryo electron microscopy, the synergistic role of NMR in this new world of structural biology is shifting from structure determination to the investigation of signaling, dynamic regulation, and the probing of transient events. Examples will be shown for the structural transition of HIV-1 and SARS-CoV-2 class I viral fusion proteins and the pressure-sensitive, reversible oligomerization of Abeta peptides implicated in Alzheimer’s disease.
Booking via Eventbrite for the in person event is required as the seating is limited.
Join Zoom Meeting
https://us05web.zoom.us/j/82901824726?pwd=Y1VUY1dwRGVGb1U1MDVsa3IySTBNUT09
Meeting ID: 829 0182 4726
Passcode: E30vpp
*Refreshments will follow on from the lecture.
*Booking is essential as seating is limited to 80 attendees.
*Open to the University of Oxford staff only.
